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Elucidating the precise pharmacological mechanism of action (MOA) of naturally occurring compounds can be challenging. Even though Tarselli et al. (sixty) produced the very first de novo artificial pathway to conolidine and showcased this naturally happening compound correctly suppresses responses to each chemically induced and inflammation-derived… Read More

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Past its pain-relieving effects, conolidine has demonstrated a favorable security margin in preclinical toxicology assessments. Not like opioids, which frequently bring about respiratory melancholy at increased doses, conolidine has not produced signs of important respiratory suppression. Also, behavioral assessments in murine designs propose an ab… Read More

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